May 24, 2018

Adding Blue Dye to Colonoscopy May Boost Detection

By having patients swallow a blue dye tablet as part of colonoscopy prep, doctors can boost their chances of catching telltale signs of cancer, new research suggests.Find the latest health articles, stories and opinions on politics, business, society, lifestyle and culture, as well as featured stories and multimedia coverage from SHINE.

The dye is technically referred to as "oral delayed-release methylene blue." When patients ingested the dye in tablet form alongside their usual pre-procedure cleansing preparation, it worked to highlight colon polyps also known as adenomas -- by upwards of 9 percent.

Use of the dye "allowed gastroenterologists to better detect and remove difficult-to-see polyps, which has great implications for further preventing this disease," said study author Dr. Alessandro Repici. He is a professor of gastroenterology and director of endoscopy at Humanitas University Medical School in Milan, Italy.

Repici and his colleagues are scheduled to present their findings June 3 at the annual Digestive Disease Week meeting, in Washington, D.C.Each year, roughly 137,000 Americans are diagnosed with colon cancer and about 50,000 die from the disease, the study authors noted in a meeting news release.

Spotting polyps during a colonoscopy can be tricky, particularly when they're flat or small (under 5 millimeters), one expert in the United States said.

"Routine screening with colonoscopy can prevent most cases of colon cancer, but the effectiveness of the exam can be limited when the pre-cancerous growths are flat (like a pancake) and blend in with the normal colon lining," explained Dr. David Robbins. He helps direct endoscopy at Lenox Hill Hospital in New York City.

Robbins said that endoscopists have already tried spraying blue dye into the colon using a catheter, as a way of highlighting polyps in a colonoscopy. But the use of a swallowed pill is an innovation.The new study involved more than 1,200 patients who were scheduled to undergo a colonoscopy at one of 20 centers around the world.

Participants were divided into three groups: one group ingested a full-dose 200-milligram dye tablet during their routine prep; another took a half-dose; and a third took an inactive "dummy" tablet.

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